This is a pain syndrome that usually affects one of the extremities. It is usually seen after minor or major tissue damage with the pain persistent after the healing of the initial damage. The diagnosis of RSD is mostly clinical, the treatment should be started early and aggressively. Physical therapy is very important in the treatment of RSD. Different classes of medications are used and injections could be tried. Ultimately this condition has excellent outcome to neuromodulation and spinal cord stimulation.